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Marginal Zone Lymphoma Pipeline Featuring 50+ Companies Expected to Change the Pace of the Treatment | Major Companies – Genentech Inc, Novartis, AstraZenenca, Roche, Celgene, and Others

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Marginal Zone Lymphoma Pipeline Featuring 50+ Companies Expected to Change the Pace of the Treatment | Major Companies – Genentech Inc, Novartis, AstraZenenca, Roche, Celgene, and Others

April 06
14:36 2023
Marginal Zone Lymphoma Pipeline Featuring 50+ Companies Expected to Change the Pace of the Treatment | Major Companies - Genentech Inc, Novartis, AstraZenenca, Roche, Celgene, and Others

DelveInsight’s, “Marginal Zone Lymphoma Pipeline Insight 2023” report provides comprehensive insights about 50+ companies and 50+ pipeline drugs in the Marginal Zone Lymphoma pipeline landscape. It covers the pipeline drug profiles, including clinical and nonclinical stage products. It also covers the therapeutics assessment by product type, stage, route of administration, and molecule type. It further highlights the inactive pipeline products in this space.

 

For Marginal Zone Lymphoma Emerging drugs, the Marginal Zone Lymphoma pipeline analysis report provides a 360° view of the therapeutics landscape by development point, product type, route of administration, molecule type, and MOA. The Marginal Zone Lymphoma pipeline research covers business opportunities, challenges, future partnerships, strong competitors, and growth strategies.

 

In the Marginal Zone Lymphoma Pipeline Report, a detailed description of the drug is given which includes the mechanism of action of the drug, Marginal Zone Lymphoma clinical trials studies, Marginal Zone Lymphoma NDA approvals (if any), and product development activities comprising the technology, PI3K inhibitors collaborations, licensing, mergers and acquisition, funding, designations, and other product-related details.

 

Key takeaways from Marginal Zone Lymphoma Pipeline Insight Report

 

  • DelveInsight’s marginal zone lymphoma pipeline report depicts a robust space with 50+ active players working to develop 50+ pipeline therapies for marginal zone lymphoma treatment.

 

  • Key marginal zone lymphoma companies such as Incyte Corporation, InnoCare Pharma, ENTEROME SA, Beijing Mabworks Biotech Co., Ltd., ADC Therapeutics, MEI Pharma, Inc., Genentech, Inc., Incyte Corporation, Novartis, AstraZeneca, Kite Pharma, Roche, Oncternal Therapeutics, Inc, Celgene, IGM Biosciences, Inc., Loxo Oncology, Genmab, ArQule, Sound Biologics, Adicet Bio, Inc, Celldex Therapeutics, TG Therapeutics, VelosBio Inc., Newave Pharmaceutical Inc, Boryung Pharmaceutical Co., Ltd, Cellectar Biosciences, Inc., Bio-Path Holdings, Inc., Nurix Therapeutics, Inc., Gamida Cell, BeiGene, Loxo Oncology, and others are evaluating novel marginal zone lymphoma drugs candidate to improve the treatment landscape.

 

  • Promising marginal zone lymphoma pipeline therapies include Tafasitamab, Orelabrutinib, EO2463, MIL62, Loncastuximab, NX-2127, LP-168, Zandelisib, BR101801, BP1002, Mosunetuzumab, CLR 131, IBI376, Pirtobrutinib, Zilovertamab vedotin, TG-1801, VAY736, ADI-001, CDX-1140, PSB202, Acalabrutinib, axicabtagene ciloleucel, Obinutuzumab, Cirmtuzumab, Nemtabrutinib, Lenalidomide, IGM-2323, Epcoritamab, GDA-201, BGB-16673,  LOXO-305, and others.

 

  • The Marginal Zone Lymphoma Companies and academics that are working to assess challenges and seek opportunities that could influence Marginal Zone Lymphoma R&D. The Marginal Zone Lymphoma pipeline therapies under development are focused on novel approaches to treat/improve the disease condition.

 

To explore more information on the latest breakthroughs in the Marginal Zone Lymphoma Pipeline treatment landscape of the report, click here @ Marginal Zone Lymphoma Pipeline Outlook

 

Marginal Zone Lymphoma Overview

Marginal zone lymphoma (MZL) is the second most common indolent non-Hodgkin’s lymphoma (iNHL). There are three types of marginal zone lymphomas: the extranodal MZL (EMZL) of mucosa-associated lymphoid tissue (MALT or gastric GALT), the splenic MZL, and the nodal MZL. EMZL can originate at virtually any extranodal site and arises in organs that normally lack lymphoid tissue (eg, stomach, intestine, thyroid, lung, and skin).

 

Recent Breakthroughs of Marginal Zone Lymphoma Treatment Landscape

 

  • In August 2022, Gamida Cell announced dosing of the first patient in a company-sponsored Phase I/II study evaluating a cryopreserved, readily available formulation of GDA-201 for the treatment of follicular, diffuse large B cell lymphomas and marginal zone lymphoma or mantle cell lymphoma.

 

  • In August 2022, Orelabrutinib’s supplemental New Drug Application (sNDA) was accepted by the China National Medical Products Administration (NMPA) for the treatment of patients with relapsed or refractory Marginal Zone Lymphoma (R/R MZL).

 

  • In June 2022, ADC Therapeutics announced the first patient has been dosed in LOTIS-7, a Phase 1b clinical trial evaluating ZYNLONTA in combination with other anti-cancer agents in patients with relapsed or refractory B-cell non-Hodgkin lymphoma. The first arm of the LOTIS-7 open-label, multi-center, multi-arm Phase Ib trial will evaluate the safety and activity of ZYNLONTA in combination with polatuzumab vedotin in patients with relapsed or refractory B-cell non-Hodgkin lymphoma, including diffuse large B-cell lymphoma, high grade B-cell lymphoma, follicular lymphoma, mantle cell lymphoma, marginal zone lymphoma, and Burkitt lymphoma.

 

  • In May 2022, Oncternal Therapeutics announced that the CIRLL clinical trial (CIRM-0001) is a Phase I/II trial evaluating zilovertamab in combination with ibrutinib in separate groups of patients with CLL or MCL. Enrollment of the dose-finding cohorts in CLL and MCL, dose-expansion cohort in CLL and MCL and randomized Phase II cohort in CLL has been completed. An additional dose-expansion cohort of up to 10 patients with marginal zone lymphoma (MZL) has recently been added. Enrollment is expected to begin in Q2 2022.

 

For further information, refer to the detailed Marginal Zone Lymphoma Unmet Needs, Marginal Zone Lymphoma Latest Drugs Launch News, and Breakthroughs, click here for Marginal Zone Lymphoma Ongoing Clinical Trial Analysis

 

Marginal Zone Lymphoma Emerging Drugs Profile

 

  • Tafasitamab: Incyte Corporation

Tafasitamab is an investigational humanized Fc-engineered monoclonal antibody directed against CD19. In 2010, MorphoSys licensed exclusive worldwide rights to develop and commercialize tafasitamab from Xencor, Inc. Tafasitamab incorporates an XmAb® engineered Fc domain, which is intended to lead to a significant potentiation of antibody-dependent cell-mediated cytotoxicity (ADCC) and antibody-dependent cellular phagocytosis (ADCP), thus aiming to improve a key mechanism of tumor cell killing. The therapy is currently in Phase III stage of clinical trial evaluation to treat Marginal Zone Lymphoma.

 

  • Amdizalisib (HMPL-689): HUTCHMED

The investigational drug candidate amdizalisib is a novel, selective small molecule inhibitor targeting the isoform phosphoinositide 3’-kinase delta (PI3Kδ), a key component in the B-cell receptor signaling pathway. We have designed amdizalisib with increased PI3Kδ isoform selectivity. Amdizalisib’s pharmacokinetic properties have been found to be favorable with good oral absorption, moderate tissue distribution and low clearance in pre-clinical pharmacokinetic studies. Amdizalisib is being investigated in studies in the U.S., Europe, China and Australia in various subtypes of advanced relapsed or refractory non-Hodgkin’s lymphoma, including follicular lymphoma and marginal zone lymphoma.

 

  • Orelabrutinib: InnoCare Pharma

Orelabrutinib is a small molecule Bruton’s tyrosine kinase inhibitor (BTKi) developed for the treatment of cancer and in development for the potential treatment of autoimmune diseases. In the field of oncology, InnoCare received approval for orelabrutinib from the China National Medical Products Administration (NMPA) in two indications: the treatment of patients with relapsed/refractory chronic lymphocytic leukemia (R/R CLL)/small lymphocytic lymphoma (R/R SLL), and the treatment of patients with relapsed/refractory mantle cell lymphoma (R/R MCL). Currently, it is in Phase II stage of clinical trial evaluation to treat Marginal Zone Lymphoma (MZL).

 

  • EO2463: Enterome

EO2463 is an innovative, off-the-shelf microbiome-peptide based cancer vaccine that combines four microbiome-peptides of B lymphocyte-specific lineage markers. EO2463 is designed to trigger the immune system into recognizing B cells as bacterial (i.e. non-self) and eliciting a targeted cell-killing response. The clinical rationale behind targeting these specific lineage cell markers is to induce the full depletion of malignant B lymphocytes that cause NHL.

 

Marginal Zone Lymphoma Pipeline Therapeutics Assessment

There are approx. 50+ key companies which are developing the therapies for Marginal Zone Lymphoma. The companies which have their Marginal Zone Lymphoma drug candidates in the most advanced stage, i.e. phase III include, Incyte Corporation.

 

Request a sample and discover the recent advances in Marginal Zone Lymphoma Ongoing Clinical Trial Analysis and Medications, click here @ Marginal Zone Lymphoma Treatment Landscape Analysis

 

Scope of the Marginal Zone Lymphoma Pipeline Report

 

  • Coverage- Global

 

  • Marginal Zone Lymphoma Companies- Incyte Corporation, InnoCare Pharma, ENTEROME SA, Beijing Mabworks Biotech Co., Ltd., ADC Therapeutics, MEI Pharma, Inc., Genentech, Inc., Incyte Corporation, Novartis, AstraZeneca, Kite Pharma, Roche, Oncternal Therapeutics, Inc, Celgene, IGM Biosciences, Inc., Loxo Oncology, Genmab, ArQule, Sound Biologics, Adicet Bio, Inc, Celldex Therapeutics, TG Therapeutics, VelosBio Inc., Newave Pharmaceutical Inc, Boryung Pharmaceutical Co., Ltd, Cellectar Biosciences, Inc., Bio-Path Holdings, Inc., Nurix Therapeutics, Inc., Gamida Cell, BeiGene, Loxo Oncology, and others

 

  • Marginal Zone Lymphoma Pipeline Therapies- Tafasitamab, Orelabrutinib, EO2463, MIL62, Loncastuximab, NX-2127, LP-168, Zandelisib, BR101801, BP1002, Mosunetuzumab, CLR 131, IBI376, Pirtobrutinib, Zilovertamab vedotin, TG-1801, VAY736, ADI-001, CDX-1140, PSB202, Acalabrutinib, axicabtagene ciloleucel, Obinutuzumab, Cirmtuzumab, Nemtabrutinib, Lenalidomide, IGM-2323, Epcoritamab, GDA-201, BGB-16673,  LOXO-305, and others.

 

  • Marginal Zone Lymphoma Pipeline Segmentation: Product Type, Molecule Type, Route of Administration

 

Dive deep into rich insights for drugs for Marginal Zone Lymphoma Market Drivers and Market Barriers, click here @ Marginal Zone Lymphoma Unmet Needs and Analyst Views

 

Table of Content

  1. Introduction
  2. Marginal Zone Lymphoma Executive Summary
  3. Marginal Zone Lymphoma Overview
  4. Marginal Zone Lymphoma Pipeline Therapeutics
  5. Marginal Zone Lymphoma Pipeline Therapeutic Assessment
  6. Marginal Zone Lymphoma – DelveInsight’s Analytical Perspective
  7. Late Stage Products (Phase III)
  8. Tafasitamab: Incyte Corporation
  9. Mid Stage Products (Phase II)
  10. Orelabrutinib: InnoCare Pharma
  11. Early Stage Products (Phase I/II)
  12. EO2463: Enterome
  13. Preclinical and Discovery Stage Products
  14. Drug name: Company name
  15. Inactive Products
  16. Marginal Zone Lymphoma Key Companies
  17. Marginal Zone Lymphoma Key Products
  18. Marginal Zone Lymphoma- Unmet Needs
  19. Marginal Zone Lymphoma- Market Drivers and Barriers
  20. Marginal Zone Lymphoma- Future Perspectives and Conclusion
  21. Marginal Zone Lymphoma Analyst Views
  22. Marginal Zone Lymphoma Key Companies
  23. Appendix

 

Got Queries? Find out the related information on Marginal Zone Lymphoma Mergers and acquisitions, Marginal Zone Lymphoma Licensing Activities @ Marginal Zone Lymphoma Emerging Drugs, and Recent Trends

 

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